This appeared originally as my answer to a question on Quora, which can be found here: Are there any advertising programs that payout more than Adsense?
Not really. Adsense is the most reputed and the most respected in the online publishing world. Their payments are timely, their CPM and CPC rates are the highest, and advertisers love them because of their perfect execution across an array of content (textual, video, mobile, etc). Some companies may claim to compensate better than Adsense, but in the long run, Adsense always wins if your content is of high quality and your website attracts genuine traffic.